摘要：Resveratrol, a compound enriched in red grape skin, has been reported to increase lifespan in yeast, worms and flies and enhance healthspan in rodents. Beneficial effects of resveratrol have been reported in aging-related cataracts, bone loss, neurodegeneration, obesity and diabetes. Resveratrol induces multiple genes expression mimicking caloric restriction (CR), which is the most conserved longevity-promoting manipulation across species [1]. Resveratrol intake conferred metabolic changes similar as CR in obese individuals [2]. Short-term consumption of resveratrol achieved a similar effect of CR [3]. In 2004, David Sinclair's group from Harvard Medical School in Boston identified resveratrol for the first time as a "direct" activator of SIRT1 using a fluorophore-conjugated synthetic peptide as targets [4]. SIRT1 is a NAD+-dependent protein deacetylase and regulates various metabolic pathways. Loss of SIRT1 abolishes many beneficial effects of CR, while transgenic mice with additional copies of SIRT1 show phenotypes resembling CR [5].
