In this paper the author discusses the issue of the pain and suffering reflected in the art. Begins with the pain phisiology, the neural path of the sensibility of the skin and muscles, to thalamus and, finally, to the parietal cerebral cortex. The literature of the pain reflected in art is very poor, especially in Egyption, classical Greck, also in Roman and Byzantine art. In the period of Renaissance art, it begins with the most tragic expression of suffering: Massucio,s fresco, then Michelangelo, Groninger, Picasso etc.