Rajeev Motwani's outstanding contributions to theoretical computer science, in diverse topics such as probabilistically checkable proofs, algorithmic combinatorics, streaming algorithms, and similarity search, to name just a few, have had an indelible influence on the field. This issue of Theory of Computing, opened on the 50th anniversary of his birth (March 24, 1962), commemorates Rajeev Motwani's life, scientific work, and legacy.