Objective: The treatment of hyperhidrosis, generalized or focal is a challenge for both physicians and surgeons. Focal hyperhidrosis—axillary, palmar, plantar, craniofacial—is the most common. Generalized hyperhidrosis is usually secondary to a systemic disorder or may be simply drug induced. Focal hyperhidrosis has its onset in childhood or adolescence and has a dramatic effect on one’s quality of life. Medical, surgical, and electrical therapies can be employed to relieve hyperhidrosis in most patients. Methods: A review of the medical and surgical literature was performed to identify the usual causes and remedies for hyperhidrosis. Results: Specific treatments, medical and surgical are recommended for all affected individuals. Conclusion: Patients with hyperhidrosis need not suffer in silence. Etiologies can be identified for most. Safe and effective therapeutic options are available.