Oral cancer is the uncontrolled tissue growth observed in the oral cavity. It may arise as a consequence of me-tastasis and/or by extension from a neighboring anatomic structure, such as the nasal cavity or the maxillary sinus. In view of putative biochemical exploration on oral carcinoma and development of certain nutraceuticals viz. omega 3 versus 6 fatty acids, cancer protective vitamins, probiotics, antioxidants, oral enzymes and mineral mainly selenium based on the hypothesis projected by non-conventional laboratory study, the present work on molecular dynamics of oral cancer was undertaken. The data thus obtained provide new insights into exploring major biochemical and/or molecular markers probably involved in diagnostics as well as therapeutics concerned with the oral carcinoma.