摘要： In vivo, in vitro, and animal learning studies
have reported neuroactive effects of Rb1 and Rg1 ginsenosides that
may be relevant to human learning and memory. The objective of this
study was to assess potential learning and memory benefits of HT1001,
a standardized proprietary North American ginseng (Panax quinquefolius)
extract containing Rb1, Rg1 and other important ginsenosides, in
healthy volunteers. Neuropsychological assessments were conducted
using the Clinical Memory Scale (CMS), which has two parallel forms
for baseline and post-treatment assessments. A young adult sample
(YAS, n = 10) and a middle aged sample (MAS, n
= 10) completed the CMS at baseline and again after 14 days’
exposure to 200mg HT1001 daily. The CMS Memory Quotient (MQ) showed
significant main effects of time, with higher CMS-MQ on the second
assessment compared to the first, and of age group, with the YAS
performing better than the MAS. There was no interaction between
time and age group. Secondary analyses indicated benefits for both
groups on free recall of word lists, cued recall of word pairs,
and recognition of figures, and benefits in the YAS but not the
MAS on free recall of pictures. Taken together, the results suggest
that memory, as measured with the CMS-MQ, was significantly improved
with open-label HT1001. While practise effects cannot be completely
ruled out, the results presented here are exciting and timely given
our increasingly ageing population, and provide preliminary support
for a prospective placebo-controlled examination of HT1001 on learning
and memory.
