摘要：
Conjugated linoleic acid (CLA) consists of a group of naturally
occurring and synthetic positional and geometric (cis-trans)
stereoisomers of the polyunsaturated fatty acid linoleic acid. The
cis-9,trans-11 (c9,t11) CLA isomer (the most prevalent
form found in ruminant-derived foods) and the trans-10,cis-12
(t10,c12) CLA isomer (present in commercial preparations) are the
two most widely studied CLA isomers in breast cancer. Studies using
both animal and cell culture models indicate that these CLA isomers,
when added to the diet or included in the cell culture medium, inhibit
mammary tumour initiation, promotion and progression in rodents,
and alter tumour cell viability in vitro. The mechanism
of CLA’s anticancer effect is not well understood, but may
involve interference with the cell cycle, induction of apoptosis,
modulation of gene expression via the activation of peroxisome
proliferator-activated receptors, lipid peroxidation, modulation
of the tumour microenvironment, changes to the structure and/or
function of the cell membrane, and interference with growth factor
receptor signaling. A greater understanding of the mechanism of
action of CLA will support the development of clinical trials to
evaluate the potential effectiveness of CLA in the treatment of
breast cancer.
