期刊名称：International Journal of Criminal Investigation
电子版ISSN：2247-0271
出版年度：2011
卷号：1
期号：1
页码：31-36
出版社：AIT Laboratories
摘要：Systemic sclerosis (SSc), a connective tissue disease, involves vascular damage, autoimmunity and fibrosis. The aims of this study were: to identify a pattern of structural and biological changes of fingerprints (FP) in definite SSc patients and to establish its validity in time at the second and third patient visit after 2, respective 6 months from the first analysis. We also evaluated the degradation of FP constituents from the first visit during a month time. In all SSc fingerprints, pore density was lower, papillary combs were more flattened and papillary grooves narrower than in controls. Epithelial cells desquamation process was accelerated in SSc versus controls. DNA levels were statistically significant higher but their decrease over time was faster in SSc FP versus controls FP. On the second and the third visits, morphological constituents of FP were significantly deteriorated versus first visit suggesting accelerated skin degradation in evolution of SSc. Fingerprint evaluation is a non-invasive, simple, observational method and it may become the foundation of future attempt to find a fingerprint pattern capable to sustain the diagnosis of SSc in subjects with early scleroderma features.
