文章基本信息
- 标题：A Polycomb complex remains bound through DNA replication in the absence of other eukaryotic proteins
- 本地全文：下载
- 作者：Bettina M. Lengsfeld ; Kayla N. Berry ; Sharmistha Ghosh 等
- 期刊名称：Scientific Reports
- 电子版ISSN：2045-2322
- 出版年度：2012
- 卷号：2
- DOI：10.1038/srep00661
- 出版社：Springer Nature
- 摘要：
Propagation of chromatin states through DNA replication is central to epigenetic regulation and can involve recruitment of chromatin proteins to replicating chromatin through interactions with replication fork components. Here we show using a fully reconstituted T7 bacteriophage system that eukaryotic proteins are not required to tether the Polycomb complex PRC1 to templates during DNA replication. Instead, DNA binding by PRC1 can withstand passage of a simple replication fork.
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