文章基本信息
- 标题：Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease
- 本地全文：下载
- 作者：André X. C. N. Valente ; Joo H. Shin ; Abhijit Sarkar 等
- 期刊名称：Scientific Reports
- 电子版ISSN：2045-2322
- 出版年度：2012
- 卷号：2
- DOI：10.1038/srep00256
- 出版社：Springer Nature
- 摘要：
An association between a rare, coding, non-synonymous SNP variant in the gene DZIP1 and Parkinson's disease was found, based on an analysis of the existing NGRC genome-wide association study dataset. The statistical analysis utilized the hypothesis-rich, targeted search unbiased assessment approach, rather than the hypothesis-free, genome-wide agnostic search paradigm. The association of DZIP1 with Parkinson's disease is discussed in the context of a Parkinson's disease stem-cell ageing theory.
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