标题：White Blood Cell Count in Women: Relation to Inflammatory Biomarkers, Haematological Profiles, Visceral Adiposity, and Other Cardiovascular Risk Factors
期刊名称：The Journal of Health, Population and Nutrition
印刷版ISSN：1606-0997
电子版ISSN：2072-1315
出版年度：2013
卷号：31
期号：1
页码：49-57
出版社：International Centre for Diarrhoeal Disease Research Bangladesh
摘要：The role of white blood cell (WBC) count in pathogenesis of diabetes, cardiovascular disease, and obesityrelated
disorders has been reported earlier. Recent studies revealed that higher WBC contributes to atherosclerotic
progression and impaired fasting glucose. However, it is unknown whether variations in WBC and
haematologic profiles can occur in healthy obese individuals. The aim of this study is to further evaluate
the influence of obesity on WBC count, inflammatory biomarkers, and metabolic risk factors in healthy
women to establish a relationship among variables analyzed. The sample of the present study consisted of
84 healthy women with mean age of 35.56±6.83 years. They were categorized into two groups based on
their body mass index (BMI): obese group with BMI >30 kg/m2 and non-obese group with BMI 2.
We evaluated the relationship between WBC and platelet count (PLT) with serum interleukin 6 (IL-6), Creactive
protein (CRP), Angiotensin II (Ang II), body fat percentage (BF %), waist-circumference (WC), and
lipid profile. WBC, PLT, CRP, and IL-6 in obese subjects were significantly higher than in non-obese subjects
(p9/L) compared to 4.4±0.3 (×109/L)
in non-obese subjects (p=0.035). WBC correlated with BF% (r=0.31, p=0.004), CRP (r=0.25, P=0.03), WC
(r=0.22, p=0.04), Angiotensin II (r=0.24, p=0.03), triglyceride (r=0.24, p=0.03), and atherogenic index of
plasma (AIP) levels (r=0.3, p=0.028) but not with IL-6. Platelet count was also associated with WC and
waist-to-hip ratio (p<0.05). Haemoglobin and haematocrit were in consistent relationship with LDLcholesterol
(p<0.05). In conclusion, obesity was associated with higher WBC count and inflammatory
parameters. There was also a positive relationship between WBC count and several inflammatory and
metabolic risk factors in healthy women.
