标题：'The Frozen Accident' as an Evolutionary Adaptation: A Rate Distortion Theory Perspective on the Dynamics and Symmetries of Genetic Coding Mechanisms
摘要：We survey some interpretations and related issues concerning ‘the frozen accident’ hypothesis proposed by Francis Crick and how it can be explained in terms of several natural mechanisms involving error- correction codes, spin glasses, symmetry breaking and the characteristic robustness of genetic networks. The approach to most of these questions involves using elements of Shannon’s rate distortion theory incor- porating a semantic system which is meaningful for the relevant alphabets and vocabulary implemented in transmission of the genetic code. We apply the fundamental homology between information source uncertainty with the free energy density of a thermodynamical system with respect to transcriptional regu- lators and the communication channels of sequence/structure in proteins. The collective outcome of these processes supports previous suggestions that ‘the frozen accident’ may in fact have been a temporal evolu- tionary adaptation.
关键词：frozen accident; rate distortion function; protein folding; free energy density; spin glass; groupoid; Onsager;relations; holonomy
