The early 20th century has witnessed major transformations in both scientific and musical domains. In particular, relativity has shown space and time to have physical reality (in contrast to a priori conditions of objects), and the hierarchical structure of tonality was abandoned in favor of progressively more systematic methods of composition evolving from twelve-tone music. By singling out the migration of the scientific understanding of space and time to musical terrain, as legitimization and metaphor for some theoretical proposals of integral serialism, a parallel is drawn between the two fields which shows the entwinement of scientific output and artistic theory and practice in post-war avant-garde.