期刊名称：International Journal of Soft Computing & Engineering
电子版ISSN：2231-2307
出版年度：2013
卷号：2
期号：6
页码：207-213
出版社：International Journal of Soft Computing & Engineering
摘要：In the dynamite field of biological and protein research, the protein fold recognition for long pattern protein sequences is a great confrontation for many years. With that consideration, this paper contributes to the protein folding research field and presents a novel procedure for mapping appropriate protein structure to its correct 2D fold by a concrete model using swarm intelligence. Moreover, the model incorporates Extended Genetic Algorithm (EGA) with concealed Markov model (CMM) for effectively folding the protein sequences that are having long chain lengths. The protein sequences are preprocessed, classified and then, analyzed with some parameters (criterion) such as fitness, similarity and sequence gaps for optimal formation of protein structures. Fitness correlation is evaluated for the determination of bonding strength of molecules, thereby involves in efficient fold recognition task. Experimental results have shown that the proposed method is more adept in 2D protein folding and outperforms the existing algorithms.
关键词：classification; CMM; criterion analysis; EGA; protein folding; sequence gaps
