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  • 标题:Fine Grain Parallel Construction of Neighbour-joining Phylogenetic Trees with Reduced Redundancy Using Multithreading
  • 本地全文:下载
  • 作者:Biswajit Sahoo ; Ashutosh Behura ; Sudarsan Padhy
  • 期刊名称:International Journal of Distributed and Parallel Systems
  • 印刷版ISSN:2229-3957
  • 电子版ISSN:0976-9757
  • 出版年度:2010
  • 卷号:1
  • 期号:2
  • 出版社:Academy & Industry Research Collaboration Center (AIRCC)
  • 摘要:In biological research, scientists often need to use the information of the species to infer the evolutionary relationship among them. The evolutionary relationships are generally represented by a labeled binary tree, called the evolutionary tree (or phylogenetic tree). The phylogeny problem is computationally intensive, and thus it is suitable for parallel computing environment. In this paper, a fast algorithm for constructing Neighbor-Joining phylogenetic trees has been developed. The CPU time is drastically reduced as compared with sequential algorithms. The new algorithm includes three techniques: Firstly, a linear array A[N] is introduced to store the sum of every row of the distance matrix (the same as SK), which can eliminate many repeated (redundancy) computations, and the value of A[i] are computed only once at the beginning of the algorithm, and are updated by three elements in the iteration. Secondly, a very compact formula for the sum of all the branch lengths of OTUs (Operational Taxonomic Units) i and j has been designed. Thirdly, multiple parallel threads are used for computation of nearest neighboring pair.
  • 关键词:Pair wise alignment; operational taxonomic unit; phylogenetic tree; multiple sequence alignment
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