标题：Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2013
卷号：110
期号：21
页码：8738-8743
DOI：10.1073/pnas.1212976110
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The peroxisome proliferator-activated receptor-{gamma} coactivator 1 (PGC-1) controls metabolic adaptations. We now show that PGC-1 in skeletal muscle drives the expression of lactate dehydrogenase (LDH) B in an estrogen-related receptor--dependent manner. Concomitantly, PGC-1 reduces the expression of LDH A and one of its regulators, the transcription factor myelocytomatosis oncogene. PGC-1 thereby coordinately alters the composition of the LDH complex and prevents the increase in blood lactate during exercise. Our results show how PGC-1 actively coordinates lactate homeostasis and provide a unique molecular explanation for PGC-1-mediated muscle adaptations to training that ultimately enhance exercise performance and improve metabolic health.
