In this study, the effects of the crude extracts, obtained from Urtica dioica, Hypericum androsaemum, Nerium oleander, Prunus laurocerasus, Aconitum nasutum, Laurus nobilis, Rhododendron caucasicum, Olea europaea, Punica granalum and Daphne glomera on the replİcation of Autographa californica nuciear polyhedrosis virüs (AcNPV) were investigated by determining the concantration of progeny virüs. As a result of this study, we detennined an inhibitory effect on the virüs concentration by utilizing the extract of U, dioica, H. androsaemum, L, nobilis, A. nasutum and R. caucasicum. On the other hand, we found that the crude extracts of N. oleander, P. laurocerasus, P. granatum, O, europaea and D. glomera estracts enhanced the virus concentration significantly.