摘要:This research documenting the neural changes during the spiritual practices and connection of various spiritual practices with psycho immunity of Aids patients. AIDS stands for acquired immunodeficiency syndrome it is a disease in which the body immune system breaks down and is unable to fight off infections, known as “opportunistic infection” that's why other illnesses take advantage of a weekend immune system. Researches says that there are many positive changes become during the spiritual practices like activation of prefrontal cortex activation of thalamus and the inhibitory thalamic reticular nucleus and a resultant functional differentiation of the parietal lobe. Spiritual practices also the cause of neuro chemical changes the neuro chemical changes contribute to the amelioration of anxiety and depression. (Mohandas 2008) These types of changes help us in curing the AIDS by making our psycho immunity strong. AIDS is caused by a virus named (HIV) Human immunodeficiency virus. HIV challenges a person at all dimension of personality like physically week, tired, passive and mentally depressive, anxious, obsessive, hopeless, socially shamed, loneliness, socially phobic and spiritually the fear of death attachment with subjects. Spiritual practices help us to strong our week psycho immunity by faith on god, prayer, belief on karma theory and optimistic attitude or practice of karma yoga, bhakti yoga, raj yoga. A study support this line (Joshi 2009) people with AIDS, those who had faith in god compression toward others, a sense of inner peace and were religious had a better chance of surviving for a longer period of time than who did not live with such belief systems. Some studies have also shown that those with HIV report greater use of spirituality when compared with similar HIV negative individuals and greater engagement in spiritual activities is tied to decreased emotional distress, lower depression, greater optimism and overall better psychological adaptation in HIV individual. Joshi (2009) Thus the present research paper tries to find out the effect of spirituality on HIV positive patients.