With Simondon, there resounds, once again, the assertion: everything is relational. More precisely, he centres all the exploration of nature, in its multiple aspects, with the fundamental principal of “being is relation.” By drawing on a lineage of philosophers, from Leibniz to Whitehead by way of Tarde, who attempted to make the relational a transcendental or genetic principle, he asserts that the question of being, without losing its pertinence, should be decentered in favour of the relational. It is this major reversal that we would like to analyse here by presenting evidence of its effects in our experience. If Simondon’s philosophy is to be relevant today it is because, in our view, it proposes the most contemporary of problems: how among the diverse registries such as the physical, the biological, the psychic and the social do we characterize relations?