The objective of this study is to explore the relationship among financial variables and systematic risk. Eight financial variables are explored as determinants of systematic risk. Results of 93 non-financial firms listed in Karachi Stock Exchange from 2005-2009 show that liquidity, leverage, operating efficiency, dividend payout and market value of equity are inversely associated while profitability, firm size and growth are positively related with systematic risk (beta). The significant association of liquidity, operating efficiency, profitability, firm size, dividend payment and market value of equity are similar with earlier studies. Findings are fruitful for investors and financial policy makers to maximize the returns.