期刊名称：International Journal on Computer Science and Engineering
印刷版ISSN：2229-5631
电子版ISSN：0975-3397
出版年度：2010
卷号：2
期号：5
页码：1871-1874
出版社：Engg Journals Publications
摘要：Glaucoma disease is deterioration of the optic nerve which slowly robs victims of their sight. Alzheimers is a slow death of brain cells that erodes memory and erases personality. Glaucoma is a chronic neurodegeneration of the optic nerve which affects the elder persons , so it has some similarity to Alzheimers since Alzheimers is also a disorder which affects elderly persons. In Glaucoma ,Optic nerves seem to accumulate the same amyloid beta protein that is the underlying cause of neuron death in the brains of Alzheimer's patients too. The role of several proteins that are likely to be involved in Glaucoma and Alzheimers are been investigated by employing multiple sequence alignment method using ClustalW tool. Phylogram tree is been constructed using functional protein sequences extracted from NCBI. Phylogram is been constructed using Neighbour-Joining Algorithm in Bioinformatics approach. Phylogram showed that Synuclein beta(SNCB) and Synuclein gamma (SNCG) plays a significant role in pathogenesis of Glaucoma and Alzheimers . It is likely that the proteins. such as GSTT1(glutathione S-transferase theta 1)and NPY (neuropeptide Y) also play a role in Glaucoma and Alzheimers next to SNCB and SNCG. This bioinformatics approach of finding genes causing diseases would help in developing Drugs that inhibit or clear the bad amyloid protein which could prove to be useful in treating both these diseases.
