摘要：Objective- To see the effect of enalapril and captopril on patients with diabetes and impending diabetic nephropathy. Material Methods- Study was performed in patients suffering with long term diabetes mellitus. A total of 61 normotensive patients of diabetes having persistent microproteinurea were selectedwith age >30 years, Informed consent was taken from all patients and a strict compliance of the drugs during the study was ensured.The patients those selected were given enalapril 2.5 mg daily or captopril 25 mg daily in two divided doses or placebo for a period of three months. The dietary instructions and anti-diabetic treatment at the beginning of the trial remained unchanged during the study. Results and Conclusion:- Both captopril and enalapril reduced protenuria significantly as compared to the placebo group. Regarding the serum creatintine level there was no significant alteration in both groups as compared to placebo.
