期刊名称：International Journal of Reviews in Computing
印刷版ISSN：2076-3328
电子版ISSN：2076-3336
出版年度：2010
卷号：2
出版社：Little Lion Scientific Research and Developement
摘要：The rapid increase in experimental data ,along with recent progress in computational methods has brought modern biology a step closer towards solving one of the most challenging problems: prediction of protein function and sequence versus structure similarity. A protein sequence is an important piece of information , it becomes more revealing and valuable when compared with others from a variety of different organisms. Protein function at its most basic level requires understanding of molecular interactions. This paper presents the up-to-date advances in computational methods for structural pattern discovery and for prediction of molecular associations. We focused on the role of multiple alignments to identify the most significant regions of a sequence - Conserved residues . Conserved residues are often key to predicting a protein function. Going further, by precisely locating these conserved residues in space, provides clues to their biological roles. The strict conservation of these residues suggests that, they have a specific role in the protein function , such as participating in an interaction with another protein or a small molecule.
