期刊名称：Aktuelnosti iz Neurologije, Psihijatrije i Graničnih Područja
印刷版ISSN：0354-2726
出版年度：2002
卷号：X
期号：1-2
页码：16-25
出版社：Clinical Center of Vojvodina
摘要：Cerebrovascular disorders (CD) represent the third leading cause of morbidity and mortality in most countries throughout the world. Among them, ischemic brain disease (IBD) comprises over 80% cases. The origin and development of IBD are mostly influenced by the presence and development of brain atherosclerosis. The initial and main pathophysiological disorder in this process is endothelial dysfunction, which causes many pathophysiological reactions, including disturbances in the hemostatic system. The objective of our study was to determine the importance of observing dynamics of these changes with respect to the grade and outcome of IBD. The study comprised 60 patients with IBD and 30 patients with non-vascular neurological disorders. We followed the dynamics of hemostatic changes analyzing activated partial thromboplastin time, euglobulin test, platelet aggregation, antithrombin III, fibrin degradation products, D-Dimer, PAI-1, protein C, protein S, factors VII and VIII with regard to the grade of IBD and neurological and functional deficit on the onset and between the 7th-10thand the 19th-21stday after the onset of CD, and 3-6 months later. Our results confirm that changes in hemostatic system have a significant predictive value, with prevailing of procoagulation factors with fibrinolysis insufficiency; Increased PAI-1 concentration and decreased antithrombin III have a significant predictive value for the grade and outcome of IBD, and faster platelet aggregation time and increased D-Dimer concentration have a borderline significance. In summary, analysis of dynamics of hemostatic changes is an easily available method with a significant value in predicting development and outcome of IBD
