期刊名称：Aktuelnosti iz Neurologije, Psihijatrije i Graničnih Područja
印刷版ISSN：0354-2726
出版年度：2002
卷号：X
期号：1-2
页码：45-51
出版社：Clinical Center of Vojvodina
摘要：The research was conducted on the sample of 150 patients diagnosed with epilepsy, treated in the period 1994-1997 at the Institute for Neurology, Psychiatry, and Mental Health, Clinical Center Novi Sad. The first group of patients was under the carbamazepine therapy, and the second one was under valproic acid. The third group, i.e. patients on polytherapy were under phenobarbitone and diphenylhydantoin. The fourth group was under phenobarbitone and valproic acid, while the fifth group was under phenobarbitone, valproic acid, and carbamazepine. The percentage of patients who did not have any adverse effects was 60% with monotherapy, 35% with the group treated with the two medications, and 30% with the group treated with the three medications. Overall 44,7% of all patients had no adverse effects. 25,3% had only one, and 30% had more than one adverse effect. More than one adverse effect (1,63) were noticed in the group treated with the combination of phenobarbitone, carbamazepine and valproic acid. The lowest average (0,43) of adverse effects was with the monotherapy with valproic acid.
