标题：Amiotrophic lateral sclerosis (ALS) belongs to the group of motor neuron diseases, affecting both the upper and the lower motor neuron. It can occur sporadically or as a hereditary disease (which is the case with 10% of all ALSs). Gene mutation for cytosolic, Cu/Zn superoxide dismutase (SOD 1) has been proved in 20% of all hereditary ALSs. Up to now, there have been identified almost 50 SOD 1 mutations in families with hereditary ALS. Clinical picture is characterized with progressive muscle mass and strength loss, fasciculations, spasticity, hyperreflection and extensory plantar response (positive Babinski's sign), as well as development of dysarthria and dysphagia. The course of the disease is progressive and the only medication approved by FDA is riluzole.
