期刊名称：Aktuelnosti iz Neurologije, Psihijatrije i Graničnih Područja
印刷版ISSN：0354-2726
出版年度：2004
卷号：XII
期号：3-4
页码：40-48
出版社：Clinical Center of Vojvodina
摘要：Vascular brain disorders hold the third place in morbidity and mortality despite the progress of diagnostic, therapeutic and preventive measures. Ischemic brain disease (IBD) is the most frequent vascular brain disease and represents the most severe and final stadium of cerebral atherosclerosis. Ethiopathogenesis of atherosclerosis is still not clear enough and one of acceptable hypotheses is the one concerning lipid peroxidation. The basic idea of this hypothesis is that oxidative modification of LDL and Lp(a) includes numerous pathophysiological factors with reactive oxidative substances playing the central role and endothelial dysfunction as the central change leading to disordered coagulation. Starting from these facts we established the hypothesis that patients with IBD have hemostatic changes which are positively correlated with the Lp(a) levels and the degree and severity of IBD. Our study comprised 60 patients with acute IBD and a control group of 30 patients with nonvascular origin of the disease and similar general characteristics. We examined the correlation between changes in the hemostatic system (thrombocyte aggregation, antithrombin III, D-dimer, protein A and S, factor VIII and PAI-1) and the degree and severity of IBD and changes in Lp(a) levels in the two groups of patients. Our results show a significant increase in procoagulant factors in patients with IBD. We also found a significant correlation between the increase in these factors and the increase in Lp(a) levels
