期刊名称：Aktuelnosti iz Neurologije, Psihijatrije i Graničnih Područja
印刷版ISSN：0354-2726
出版年度：2005
卷号：XIII
期号：3-4
页码：37-44
出版社：Clinical Center of Vojvodina
摘要：Waldenstr.m's disease is a rare lymphoplasmoproliferative disease, which by cytomorphologic characteristics of its malignant cell belongs to lymphomas, but owing to ability of this cell to produce specific protein which by its properties differs from other normal proteins and which is specified as paraprotein, belongs to paraproteinemias. Since paraprotein is in fact monoclonal gammaglobulin, that is, monoclonal immunoglobulin, this disease is classified into monoclonal gammopathies, such as are multiple myeloma, heavy-chain disease, essential monoclonal cryoglobulinemia and essential monoclonal amyloidosis. According to its physicochemical and immunobiologic properies monoclonal immunoglobulin M (mIgM) characteristic of the Waldenstr.m's disease is specific and it theoretically contributes to more expressed damages to only protein component. It potentially exerts the most unfavorable effect upon cardiovascular system, primarily due to increased blood viscosity. In the period from 1986 to 2003, 29 patients with Waldenstr.m's disease were examined and treated at the Military Medical Academy. Considering that this is a very rare disease this is an exceptionally large number of patients in this environment, but this is also an opportunity to comprehend some of its peculiarities and their effect upon the course of the disease. Previously unnoticed phenomenon, that is, existence of the decreased cholesterol level was observed in most patients with Waldenstr.m's disease as well as in those with relatively favorable clinical course although complications of the disea se were present. Hypocholesterolemia was co mpared with all relevant parameters in the manifest d isease, but no correlation between cardioprotective effect of hypocholesterolemia and risk factors of the disease itself could be found. Cardioprotective effect of hypocholeterolemia is most probably indirect, due to reduced conditions for development of atherosclerosis, taking into account that hypocholeterolemia is the greatest risk factor of irreversible blood vessels damage
关键词：Waldenstr.m's disease; cholesterol; atherosclerosis; cardiovascu lar system
