期刊名称：Aktuelnosti iz Neurologije, Psihijatrije i Graničnih Područja
印刷版ISSN：0354-2726
出版年度：2009
卷号：XVII
期号：1-2
页码：57-64
出版社：Clinical Center of Vojvodina
摘要：The neuroimaging techniques that are used in the visualization of patients with dementia can be divided into: 1) structural (magnetic resonance imaging (MRI), Diffusion Tensor Imaging MRI (DTI MRI)); 2) neurochemical (photon emission tomography (PET), Single photon emission computed tomogdraphy (SPECT), MRI Spectroscopy); 3) functional (perfusion d PET/SPECT, cerebral activity d functional MRI). Indications for MRI in patients with dementia are: the exclusion of reversible causes of dementia (reversible dementias), modification of the course of disease, disease onset before the age of 65, atypical clinical picture, and monitoring of treatment response. In the most important type of degenerative demendtias – Alzheimer>s disease, MRI shows evidence of atrophy of the hippocampus, amygdala and tempodral lobe, whereas PET shows reduced cerebral metabolism and blood flow in the frontal regions that cordrelate with the severity of cognitive impairment. In another important patient population, patients with vascular dementia, MRI differentiates subgroups of patients with small and large vessel infarctions, dedpending on the supplying cerebral arteries. Another type of dementia that can be verified on MRI is dedmentia associated with normotensive hydrocephalus with enlarged lateral ventricles not correlating with the degree of cortical atrophy. CreutzfeldtdJakob disease manifests as lesions of the corpus striatum, thadlamus, cortex and periventricular white mass, with rapid progression of cortical and subcortical atrophy
