期刊名称：Aktuelnosti iz Neurologije, Psihijatrije i Graničnih Područja
印刷版ISSN：0354-2726
出版年度：2010
卷号：XVIII
期号：4
页码：10-14
出版社：Clinical Center of Vojvodina
摘要：Transcranial sonography (TCS) is a reliable method in the diagnosis of Parkinson's disease (PD) and the differential diagnosis of atypical parkinsonism. Finding of hyperechogenicity of the substantia ni-gra (SN), which is the result of iron deposition in this midbrain structure, is highly suggestive of PD. We performed a study on 67 PD patients and 33 healthy controls in order to determine sensitivity and specific-ity of TCS in diagnosis of PD. Due to insufficient or completely impenetrable acoustic temporal bone TCS could not be performed in 10.2% of PD patients and 15.1% of healthy controls. Significant SN hyperecho-genicity was recorded in 77.6% of PD patients and 12.1% of healthy controls. The sensitivity of TCS was 86.6% and specificity 86.2%, with the positive predictive value of 92.8%. In the PD group, SN hyperechoge-nicity was generally more pronounced on the side which was contralateral to the side of dominant clinical presentation. Our results are in line with the data reported by other investigators. With its high reliability, harmlessness and low cost, TCS is a diagnostic method that is today widely used in the diagnosis of PD.
