期刊名称：Aktuelnosti iz Neurologije, Psihijatrije i Graničnih Područja
印刷版ISSN：0354-2726
出版年度：2011
卷号：XIX
期号：2
页码：43-48
出版社：Clinical Center of Vojvodina
摘要：Atrial fi brillation (AF) is the most common sustained cardiac arrhythmia, occurring in 1–2% of the general population. AF confers a 5-fold risk of stroke, and one in fi ve of all strokes is attributed to this arrhythmia. Ischemic strokes in association with AF are oft en fatal, and those patients who survive are left more disabled by their stroke and more likely to suff er a recurrence than patients with other causes of stroke. Th e prevalence of AF increases with age.Men are more oft en aff ected than women. AF is associat-ed with a variety of cardiovascular conditions: valvular heart diseases, cardiomyopathies, including prima-ry electrical cardiac diseases,whichcarry an increased risk for AF, especially in young patients. Atrial sep-tal defect is associated with AF in 10–15%. Th is association has important clinical implications for the an-tithrombotic management of patients with a previous stroke or transient ischemic attack (TIA) and an atri-al septal defect. AF may manifest initially as an ischemic stroke or TIA, and it is reasonable to assume that most patients experience asymptomatic, oft en self-terminating, episodes of arrhythmia, before AF is fi rst diagnosed. Most patients with acute AF will require anticoagulation unless they are at low risk ofthrom-boembolic complications (no stroke risk factors) and no cardioversion is necessary. Much earlier detection ofthe arrhythmia might allow the timely introduction of therapiesto protect the patient, not only from the consequences of thearrhythmia, but also from progression of AF from aneasily treated condition to an ut-terly refractory problem.
关键词：atrial fi brillation; ischemic stroke; antithrombotic management
