摘要:Opioid peptides have been implicated in many biological processes acting as hormones, neurohormones or neurotransmitters. The aim of this research was to investigate effect of endurance training on plasma beta endorphin (BA) changes in active and sedentary girls. 12 healthy physical education students as active group (n = 12, active group with, 21.6 ± 0.6 year age, 162.25 ± 3.68 cm in height, and 54.13 ± 6.35 kg, weight) and 12 healthy non physical education as sedentary group (n = 12, sedentary group, age 20.55 ± 0.69 year, high, 161.40 ± 3.14 cm, weight, 59.25 ± 4.45 kg) requited. Subjects entered the study on their usual diet and after familiarization with training protocol, Bruce test (treadmill test) as aerobic test applied. The blood sample was collected before and after training in both groups. Beta-endorphin concentration was determined by radioimmunoassay kits. The analyses and data processing showed that there is no significant difference within active (0.77 ± 0.1 pmol/l) and sedentary group (0.82 ± 0.01 pmol/l) in basal BE at rest. The BE levels after endurance training in active group and sedentary group increase respectively (0.83 ± 0.09 pmol/l), (compared with basal) however, significant difference was found between pre and post test group in active group (P > 0.05). In this research, BE secretion increased in response to endurance exercise both in active and sedentary girls.