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  • 标题:Comparison of Oral Tolerance to ApoB and HSP60 Peptides in Preventing Atherosclerosis Lesion Formation in <i>Apob48<sup>&#x2212;</sup>/Ldlr<sup>&#x2212;</sup></i> Mice
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  • 作者:Lakshmi Mundkur ; Rupak Mukhopadhyay ; Vrushali Deshpande
  • 期刊名称:Journal of Vaccines
  • 印刷版ISSN:2090-7974
  • 电子版ISSN:2090-7990
  • 出版年度:2013
  • 卷号:2013
  • DOI:10.1155/2013/212367
  • 出版社:Hindawi Publishing Corporation
  • 摘要:Antigen-specific immune modulation is emerging as an attractive therapeutic option to prevent atherosclerosis. We compared the efficacy of oral administration of peptides derived from apolipoprotein B (ApoB; 661&#x2013;680) and heat shock protein 60 (HSP60; 153&#x2013;163), in the prevention of atherosclerotic lesion formation hyperlipidemic low density lipoprotein receptordeficient (LDLr&#x2212;/&#x2212;), apolipoprotein B-100 only (apoB100/100) mice model. Oral administration of peptides induced tolerance as seen by an increase in regulatory T cells in the peripheral immune system. Tolerance to ApoB peptide reduced plaque development by 28.7&#x25; () while HSP60 was effective in reducing lesion development by 26.8&#x25; in ApoB48/LDLr&#x2212;/&#x2212; mice. While tolerance to HSP60 resulted in increase in anti-inflammatory cytokines (IL10 and TGF-&#x3b2;), ApoB tolerance was effective in reducing the lipid deposition in the lesion. Our results suggest that the two peptides have distinct mechanisms of controlling the development of atherosclerosis in mice.
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