摘要：Ba c k g r o u n d: Climate change may affect Plasmodium vivax malaria transmission in a wide region including both subtropical and temperate areas.oB j e c t i v e s: We aimed to estimate the effects of climatic variables on the transmission of P. vivax in temperate regions.Me t h o d s: We estimated the effects of climatic factors on P. vivax malaria transmission using data on weekly numbers of malaria cases for the years 2001–2009 in the Republic of Korea. Generalized linear Poisson models and distributed lag nonlinear models (DLNM) were adopted to estimate the effects of tempera ture, relative humidity, tempera ture fluctuation, duration of sunshine, and rainfall on malaria transmission while adjusting for seasonal variation, between-year variation, and other climatic factors.re s u l t s: A 1°C increase in tempera ture was associated with a 17.7% [95% confidence interval (CI): 16.9, 18.6%] increase in malaria incidence after a 3-week lag, a 10% rise in relative humidity was associated with 40.7% (95% CI: –44.3, –36.9%) decrease in malaria after a 7-week lag, a 1°C increase in the diurnal tempera ture range was associated with a 24.1% (95% CI: –26.7, –21.4%) decrease in malaria after a 7-week lag, and a 10-hr increase in sunshine per week was associated with a 5.1% (95% CI: –8.4, –1.7%) decrease in malaria after a 2-week lag. The cumulative relative risk for a 10-mm increase in rainfall (≤ 350 mm) on P. vivax malaria was 3.61 (95% CI: 1.69, 7.72) based on a DLNM with a 10-week maximum lag. co n c l u s i o n s: Our findings suggest that malaria transmission in temperate areas is highly depen-dent on climate factors. In addition, lagged estimates of the effect of rainfall on malaria are consis-tent with the time necessary for mosquito development and P. vivax incubation
关键词：climate change; climatic variables; distributed lag nonlinear model; generalized linear ;Poisson model; incubation period; Plasmodium vivax malaria; temperate region
