摘要：Ba c k g r o u n d: Although hyperthermia is a recognized animal teratogen and maternal fever has been associated with birth defects in humans, data on the relationship between high environmental temperatures and birth defects are limited.oB j e c t i v e: To determine whether pregnancies are potentially vulnerable to the weather extremes anticipated with climate change, we evaluated the relationship between extreme summer tempera-ture and the occurrence of birth defects.Me t h o d s: We performed a population-based case–control study by linking the New York State Congenital Malformations Registry to birth certificates for the years 1992–2006. We selected non-malformed infants from a 10% random sample of live births as controls. We assigned meteorologic data based on maternal residence at birth, summarized universal apparent temperature (UAT; degrees Fahrenheit) across the critical period of embryogenesis, and estimated adjusted odds ratios (aOR) and 95% confidence intervals (CI) with multivariable logistic regression, controlling for con-founders available on the birth certificate.re s u l t s: Among 6,422 cases and 59,328 controls that shared at least 1 week of the critical period in summer, a 5-degree increase in mean daily minimum UAT was significantly associated with con-genital cataracts (aOR = 1.51; 95% CI: 1.14, 1.99). Congenital cataracts were significantly associ-ated with all ambient temperature indicators as well: heat wave, number of heat waves, and number of days above the 90th percentile. Inconsistent associations with a subset of temperature indicators were observed for renal agenesis/hypoplasia (positive) and anophthalmia/microphthalmia and gas-troschisis (negative).co n c l u s i o n s: We found positive and consistent associations between multiple heat indicators dur-ing the relevant developmental window and congenital cataracts which should be confirmed with other data sources.
关键词：birth defects; climate change; congenital cataracts; heat; temperature
