摘要：Ba c k g r o u n d: Recent findings suggest that maternal smoking during pregnancy may play a role in the development of metabolic altera tions in offspring during childhood. However, whether such exposure increases the risk of developing similar metabolic altera tions during adulthood is uncertain.oB j e c t i v e: We evalua ted the associa tion of in utero exposure to maternal tobacco smoke with plasma lipids, apolipoprotein B (apoB), and C-reactive protein (CRP) in adulthood.Me t h o d s: The study was based on a sub sample of the Norwegian Mother and Child Cohort Study (MoBa) and included 479 pregnant women with plasma lipids, apoB, and CRP measure-ments. Informa tion on in utero exposure to tobacco smoke, personal smoking, and other factors were obtained from the women by a self-completed questionnaire at enrollment, at approximately 17 weeks of gesta tion.re s u l t s: Women exposed to tobacco smoke in utero had higher tri glyce rides [10.7% higher; 95% confidence interval (CI): 3.9, 17.9] and lower high-density lipoprotein choles terol (HDL) (–1.9 mg/dL; 95% CI: –4.3, 0.5) compared with unexposed women, after adjusting for age, physi-cal activity, educa tion, personal smoking, and current body mass index (BMI). Exposed women were also more likely to have tri glyce rides ≥ 200 mg/dL [adjusted odds ratio (aOR) = 2.5; 95% CI: 1.3, 5.1] and HDL < 50 mg/dL (aOR = 2.3; 95% CI: 1.1, 5.0). Low-density lipoprotein choles terol, total choles terol, and apoB were not associa ted with the exposure. CRP was increased among exposed women; however, after adjustment for BMI, the associa tion was completely attenua ted.co n c l u s i o n s: In this popula tion, in utero exposure to tobacco smoke was associa ted with high tri-glyce rides and low HDL in adulthood, 18–44 years after exposure
