摘要：a c k g r o u n d: Elevated blood pressure (BP) has been associated with particu late matter (PM) air pollu tion, but associations with PM chemical constitu ents are still uncertain.oB j e c ti v e s: We investigated associations of BP with various chemical constitu ents of fine PM (PM2.5) during 460 repeated visits among a panel of 39 university students.Me t h o d s: Resting BP was measured using standardized methods before and after the university students relocated from a suburban campus to an urban campus with different air pollu tion con-tents in Beijing, China. Air pollu tion data were obtained from central monitors close to student residences. We used mixed-effects models to estimate associations of various PM2.5constitu ents with systolic BP (SBP), diastolic BP (DBP), and pulse pressure.re s u l t s: An interquartile range increase of 51.2 μg/m3in PM2.5was associated with a 1.08-mmHg (95% CI: 0.17, 1.99) increase in SBP and a 0.96-mmHg (95% CI: 0.31, 1.61) increase in DBP on the following day. A subset of PM2.5constitu ents, including carbonaceous fractions (organic carbon and elemental carbon), ions (chloride and fluoride), and metals/metalloid elements (nickel, zinc, magnesium, lead, and arsenic), were found to have robust positive associations with different BP varia bles, though robust negative associations of manganese, chromium, and molybdenum with SBP or DBP also were observed.co n c l u s i o n s: Our results support relationships between specific PM2.5constitu ents and BP. These findings have potential implications for the development of pollu tion abatement strategies that maximize public health benefits
