摘要：Purpose: Cystic fibrosis (CF) is a genetic, metabolic disease. Long-term therapy often leads to inappropriate calcification of bones. Dual X-ray absorptiometry (DXA) is considered a .gold -standard" for bone mineral density (BMD) assessment, but high usage costs can limit its availability. This paper compares two methods for BMD assessment in CF patients: hand radiograms method and densitometry using DXA method. Materials and methods: The study was performed in a group of 26 CF patients (10F, 16M), aged 7 -30 years. In all cases, DXA measurements were performed, along with bone mass assessment using DENSY2004 system for digital assessment of hand radiograms. Stepwise binary logistic regressio n was used to examine the contribution of bone age, BMI, Cole's index and hand radiograms parameters to lo w BMD expressed as Z-score ¡Ü-1SD. Results: Statistical analysis of the gathered data revealed that hand radiograms method allow for estimation of Z-score below -1SD with accuracy of 84.62% co mparing to DXA. Sensitivity and specificity of this estimation in the studied group of CF patients was 86.67% and 81.82%. Conclusions: Hand radiograms method has good accuracy, sensitivity and specificity; therefore, it can be an alternative for DXA in BMD assessment. It can be implemented in chronic diseases affecting BMD like cystic fibrosis
关键词：cystic fibrosis; bone mineral density; ;osteoporosis; dual X-ray absorptiometry; hand ;radiograms
