Supporting Innovation is one of the effective factors in rapid development of Entrepreneurship in developed countries. In an innovative Organization, presenting new products, and new production methods, accessing to new markets, and to new sources for providing raw material or other inputs, will happen. Besides, new structures for industry and developing entrepreneurship will be provided. In the First stage of the present study, library and internet research is done on economic organizations and on the developments. In the second stage a series of interviews are done according to a number of designed questionnaires. The entrepreneurs, official executives on different levels who were related to National Innovation system participated in the interviews. Consequently, by examining the existing innovation entrepreneurship in Iran and by considering the legal conditions of Innovative support based on the four foundations that are accepted by developed countries, the Guidelines for improving innovation – based entrepreneurship are proposed.