摘要：Background. High consumption of food products rich in rapidly digested starch, saccharose, glucose and fructose, animal fat and low physical activity are the major risks of overweight, obesity and cardiovascular diseases. The aim of this study was to evaluate the effect of resveratrol on the activity of selected enzymes, heme oxygenase-1 (Hmox1) and glutathione reductase (Gsr) gene expression, as well as fatty acids composi- tion in the visceral adipose tissue in rats fed a high fructose diet.Material and methods. Laboratory male Wistar rats (n = 30) were fed for four months with the high fructose diet (HF diet) (63% w/w) based on American Institute of Nutrition diet (AIN-93G diet). Group I was fed with the AIN-93G diet (NFC – negative control group), group II – high fructose diet (HF), group III – HF with 0.02% of resveratrol, group IV – high fructose with 0.04% of resveratrol and group V – high fructose with 0.06% of resveratrol. At the end of the experiment fasted rats were anaesthetized, blood and livers were col- lected and stored until analyses.Results. Concentration of glucose was significantlyincreased in the blood of rats fed with the HF containing 0.02% and 0.06% of RSV in diets compared to animals fed with the HF diet. Activity of heme oxygenase-1 (HO-1) was significantlylower in the serum of rats fed with the HF diet containing 0.06% RSV compared to the serum of rodents fed with the negative control diet and the HF diets. Gsr and Hmox1 gene expression was significantly increased in livers of rodents fed with HF containing 0.04% RSV compared to the HF group.
