Kidneys endowed with million units termed as “nephrons” that act as natural sieves. The kidneys provide the final common pathway for the excretion of many drugs and their metabolites and therefore are frequently subjected to high concentrations of potentially toxic substances. Administration of several antibiotics like Gentamicin causes kidney dysfunction. Rats treated with Gentamicin developed significant kidney dysfunction was observed from increased level of urea, creatinine, sodium and decreased level of protein, potassium and non enzymatic antioxidants such as vitamin C and vitamin E. The plant, Ipomoea digitata is found to have nephroprotective activity.