期刊名称：Journal of Modelling and Simulation of Systems
印刷版ISSN：1737-9377
电子版ISSN：1737-9385
出版年度：2010
卷号：1
期号：2
出版社：HyperSciences Publisher
摘要：Now a day's swine flu is becoming endemic disease and its infection is caused by influenza (flu) viruses (H1N1). There are many different subtypes of type 'A' influenza viruses. These subtypes differ because of changes in certain proteins on the surface of the influenza 'A' virus (hemagglutinin[HA] and neuraminidase [NA] proteins). Influenza 'A' virus, also called as "h1n1 virus" whose nucleocapsid is responsible for Swine flu disease. The protein ID from swissprot data base were selected for obtaining the descriptio n and function of the protein, its domains structure, post-translational modifications, variants, etc. BLAST analysis was performed to identify more protein sequence in influenza A (H1N1) virus and to analyze the protein sequence involved in known organisms. The comparative modelling of the nucleocapsid - of influenza A (H1N1) virus was performed by using the comparative modelling program MODELLER, SPDV, Swiss Model, Schrodinger. The obtained models were verified with the structure validation programs like, PROCHEK & SAVS. SCHRODINGER was used for energy refinement of the model. Active site determination through CASTp and surface visualisation by Molegro Virtual Docker suggests that this protein can act as a potential drug target
关键词：H1N1; Influenza Virus Homology Modelling; Matrix Protein; Active site determination
