期刊名称：Journal of Materials and Environmental Science
印刷版ISSN：2028-2508
出版年度：2013
卷号：4
期号：4
页码：542-557
出版社：University of Mohammed Premier Oujda
摘要：Metal ions are required for many critical functions in humans. Scarcity of some metal ions can lead to disease. Well-known examples include pernicious anemia resulting from iron deficiency, growth retardation arising from insufficient di- etary zinc, and heart disease in infants owing to copper deficiency. The ability to recognize, to understand at the molecular level, and to treat diseases caused by inadequate metal-ion function constitutes an important aspect of medicinal bioinorganic chemistry. Understanding the biochemistry and molecular biology of natural detoxification mechanisms of metals can help in designing and applying chelating agents to treat metals to be excellent antitumor agents for several cancer types
