摘要：In this research, copolymers o f poly (D,L-lactide-co-ε-caprolactone) (PLCL) w ith 50:50 feed ratio were synthesized b y the coordination-insertion ring opening polymerization (ROP) of cyclic esters at different temperature (130 0C, 150 0C and 200 0C). Both Sn(II)octoate (SnOct2) and isoprop anol (iPrOH) were used as catalyst and initiator respectively and polymerization reaction were took p art from 24 hours until 1 week. The conversion of monomer D,L-lactide and ε-caprolactone, polydispersit y index (PDI) and total average molecular weight o f copolymer PLCL can be determined by proton nuclear magnetic resonance (1H-N MR) and size exclusion chromatography coupled multi-angle laser light scattering (SEC-MALLS). Both analyses showed the increasing trend as the reaction temperature increased. The average sequence lengths of the lactidyl units (leLL) and caproyl (lecap) units, the degree of randomness (R) and the transesterification coefficients (TIand TII) were calculated from the 13C-NMR sp ectra. The average sequence lengths showed the decreasing trends, meanwhile there were small significant value increased for degree of randomness and transesterification coefficients when reaction temperature increased from 130 0C to 200 0C. The fabricated PLCL cop olymers have a potential to be transformed into three dimensional scaffo ld for application in tendon/ligament tissue eng ineering
关键词：coordination;-;insertion;ring opening polymerization; transesterification; averag e sequence length; ;degree of randomness
