摘要：Introduction: Beta-glucuronidase (G LU) is a member of the lysosomal glycosidase family that catalyzes hydrolysis of β-D-glucuronic acid residues from the non-reducing end of glycosaminoglycans. Increased activities of GLU have been earlier reported in the serum of alcohol-dep endent patients after a chronic heavy drinking period but not after acute into xication (called binge drinking). The accelerating binge drinking pheno-menon is an alarming public health issue that requires better prevention. Purpose: To determine the activity serum and urinary GLU, after an acute, single, and a large dose of alcohol intoxication. Materials and methods: The serum and urine of eight healthy binge drinkers were collected before binge drinking, and 2 and five days after the drinking session. The activity o f GLU was determined by the colorimetric method. Results: There was a tendency to decrease in the serum GLU activity two days after acute alcohol intoxication (binge drinking), which was followed by the significant increase in the G LU activity five days after drinking. The urinary activity of GLU was not changed after intoxication. Conclusion: Alcohol-induced imbalance in the serum GLU activity might be associated with alcohol-induced liver hypoxia and subsequent reperfusion, and can be d etected even five days after the drinking session
