摘要：Dietary restriction (DR) is a well-known intervention to slow down the aging of cells and organisms. Although the molecular mechanisms by which DR prolongs lifespan are poorly understood, the Target of Rapamycin Complex 1 (TORC1) signaling pathway that controls protein translation, autophagy and mitochondrial function, among other growth-related processes, is considered a main player mediating DR effects in diverse model organisms. Inhibition of TORC1 by nutrient limitation or by drugs prolongs lifespan [1], and reduced protein translation has been linked to increased lifespan in several organisms [2].
