摘要：The p53 protein was discovered many years ago as a tumour suppressor gene and despite the wealth of information that has accumulated, a complete understanding of how p53 functions remains still elusive. p53 is a key regulator of the checkpoint response to DNA damage in mammal cells and is affected by loss-of-function mutations in the majority of human cancer. In various normal adult tissues, basal levels of p53 protein are low, but specific stress signals induce post-translation modifications and its stabilization, leading to activation of distinct transcriptional programmers. In response to stress signals p53 mainly acts to repair DNA damage and depending on the severity of the damage, the cell microenvironment and the cell type, p53 can orchestrate different cellular outcomes such as apoptosis and senescence
