摘要：Cellular senescence acts as a physiological barrier against uncontrolled proliferation of cells with potentially harmful alterations, contributing to tumor suppression and tissue homeostasis in live organisms [1]. Senescence is a complex phenotype that involves major changes in cellular function and structure. This phenotype is characterized by a specific gene expression program, which is controlled by key transcriptional regulators as well as by global and gene-specific epigenetic changes. In addition, the post-transcriptional control of senescence mediated by non-coding RNAs has recently attracted much interest [1]. In this context, our recent results [2] provide new evidence that supports the notion that microRNA-mediated control of gene expression plays a critical regulatory role in cellular senescence
