摘要：We describe 27 cases of multiple drug-resistant pneumococcal infection in Queensland children(7 cases) and adults (20 cases), between February 1995 and October 1996. Seven patients hadinvasive disease. Serotypes were those commonly associated with paediatric infections andincluded types 19F (15 strains), 14 (6), 23F (4), 6A (1) and 19A (1). No rifampicin or vancomycinresistance was encountered. However, pneumococci fully resistant to cotrimoxazole, erythro-mycin and tetracycline were isolated from 25 of 27 cases (93%). Strains with high levelresistance to penicillin and chloramphenicol were also recovered from 16 (59%) and 19 (70%)patients r espectively. Twelve of 16 penicillin-resistant isolates showed intermediate resistanceto ceftriaxone and two strains were fully resistant to this antibiotic. Clones of types 19F and 14pneumococci, each with two distinctive resistance patterns, appear to be established in south-east Queensland
