文章基本信息

标题：Dietary and genetic effects on age-related loss of gene silencing reveal epigenetic plasticity of chromatin repression during aging
本地全文：下载
作者：Nan Jiang ; Guyu Du ; Ethan Tobias 等
期刊名称：Aging
出版年度：2013
卷号：5
期号：11
页码：813-824
出版社：U.S.Department of Health & Human Service
摘要：During. aging,. changes. in. chromatin. state. that. alter. gene. transcription. have. been. postulated. to. result. inexpression. of. genes. that. are. normally. silenced,. leading. to.deleterious. age©\related. effects. on.cellular. physiology.. Despitethe. prevalence.of.this. hypothesis,.it. is. primarily.in. yeast. that. loss. of. gene.silencing. with. age.has. been. well. documented.We. use. a. novel. position. effect. variegation. (PEV). reporter. in. Drosophila. melanogaster. to. show. that. age©\related. loss. ofrepressive.heterochromatin.is.associated. with. loss. of.gene. silencing.in.metazoans. and. is.affected.by.Sir2,.as. it.is. in. yeast.The.life. span©\extending. intervention,.calorie.restriction.(CR),. delays. the. age©\related.loss.of.gene.silencing,.indicating. thatloss.of.gene.silencing.is.a.component.of.normal.aging..Diet.switch.experiments.show.that.such.flies.undergo.a.rapid.changein. their. level. of. gene. silencing,. demonstrating. the. epigenetic. plasticity. of. chromatin. during. aging. and. highlighting. thepotential. role. of. diet. and. metabolism. in. chromatin. maintenance,. Thus,. diet. and. related. interventions. may. be. oftherapeutic.importance.for.age©\related.diseases,.such.as.cancer